TxVC[P2A] (P06817) Protein Card

General Information
Name TxVC[P2A]
Organism synthetic construct
Protein Type Synthetic
Parent TxVC
Notes Mutant of TxVC with a Proline replaced by an Alanine at position 2 has been shown to abolish inhibitory activity of its nAChR targets (Wang et at., 2014).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework V
Pharmacological family

Sequence
KACCSIHDNSCCGL
Average Mass 1449.64
Monoisotopic Mass 1448.53
Isoelectric Point 7.98
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α2β2C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α2β4C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α3β2C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α3β4C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α4β2C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α4β4C. textile>10000 nMACh (100 uM)Wang,S. et al. (2014)
α7C. textile>10000 nMACh (200 uM)Wang,S. et al. (2014)
α9α10C. textile>10000 nMACh (30 uM)Wang,S. et al. (2014)

References
Wang,S., Du,T., Liu,Z., Wang,S., Wu,Y., Ding,J., Jiang,L. and Dai,Q. (2014) Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes. Biochem. Biophys. Res. Commun. 454:151-156

Internal links
Nucleic acids
Structure

External links

Tools