TxID (P06831) Protein Card

General Information
Name TxID
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxID precursor (6832)

Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1489.77
Monoisotopic Mass 1488.54
Isoelectric Point 8.31
Extinction Coefficient [280nm] 500.00


IC50: Nicotinic acetylcholine receptors

α1β1δεM. musculus> 10 uM Ach (100 uM)Luo,S. et al. (2013)
α2β2R. norvegicus > 10 uM Ach (100 uM)Luo,S. et al. (2013)
α2β4R. norvegicus4.55 uM+/-3.951.95Ach (100 uM)Luo,S. et al. (2013)
α3β2R. norvegicus > 10 uMAch (100 uM)Luo,S. et al. (2013)
α3β4R. norvegicus12.5 nM+/-9.41.05Ach (100 uM)Luo,S. et al. (2013)
3.6 nM0.7Yu et al. (2018)
α4β4R. norvegicus>10 uMAch (100 uM)Luo,S. et al. (2013)
α6/α3β2β3R. norvegicus> 10 uMAch (100 uM)Luo,S. et al. (2013)
α6/α3β4R. norvegicus94.1 nM+/-731.3Ach (100 uM)Luo,S. et al. (2013)
34 nM1.1Yu et al. (2018)
α7R. norvegicus> 10 uM Ach (100 uM)Luo,S. et al. (2013)
α9α10R. norvegicus> 10 uM Ach (100 uM)Luo,S. et al. (2013)

Synthetic variants

Luo,S., Zhangsun,D., Zhu,X., Wu,Y., Hu,Y., Christensen,S., Harvey,P.J., Akcan,M., Craik,D.J. and McIntosh,J.M. (2013) Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J. Med. Chem. 56:9655-9663
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Protein Precursor TxID precursor (6832)
Nucleic acids
Structure Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors

External links