Conorphin-1 (P06865) Protein Card

General Information
Name Conorphin-1
Organism synthetic construct
Protein Type Synthetic
Notes The study by Deuis et al (2015) suggests that targeting the K-opoid receptors in peripheral sensory nerve endings innervating the skin with conorphin-1 is not a viable analgesic approach.

Classification
Conopeptide class conorphin
Gene superfamily
Pharmacological family

Sequence
(Bnz)PrrQ(TBG)CC
Modified residues
positionsymbolname
1BnzN-term benzoyl
3rD-arginine
4rD-arginine
6TBGTert-Butyl Glycine
Sequence evidence protein level
Average Mass 994.17
Monoisotopic Mass 993.44
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

EC50: Opioid receptors

TargetOrganismEC50Ref
κH. sapiens2.2 M+/-0.07Jennifer R. Deuis et al. (2015)

Percentage inhibition: Opioid receptors

TargetOrganism% inhibitionConcentrationAgonistRef
δH. sapiens(No significant effect of Conorphin-1 concentrations of up to 1uM)0Forksolin (50 uM)Jennifer R. Deuis et al. (2015)
μH. sapiens(No significant effect of Conorphin-1 concentrations of up to 1uM)0Forksolin (50 uM)Jennifer R. Deuis et al. (2015)

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationAgonistRef
Nav1.1H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.2H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.3H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.4H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.5H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.6H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.7H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0Veratridine (60 uM)Jennifer R. Deuis et al. (2015)
Nav1.8H. sapiens(No inhibition using Conorphin-1 concentrations of up to 1uM)0deltamethrin (150 uM)Jennifer R. Deuis et al. (2015)

References
Jennifer R. Deuis, Ella Whately, Andreas Brust, Marco C. Inserra, Naghmeh H. Asvadi, Richard J. Lewis, Paul F. Alewood, Peter J. Cabot, Irina Vetter (2015) Activation of κ opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia ACS Chemical Neuroscience 6:1751-1758

Internal links
Nucleic acids
Structure

External links

Tools