Conorphin-T[ribbon] (P06897) Protein Card

General Information
Name Conorphin-T[ribbon] (named by ConoServer)
Alternative name(s) 1(1-4,2-3)
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Conorphin-T precursor (6097)
Conorphin-T precursor (646)
Conorphin-T precursor (1678)

Classification
Conopeptide class conorphin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
NCCRRQICC(nh2)
Modified residues
positionsymbolname
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1093.32
Monoisotopic Mass 1092.42
Isoelectric Point 12.50
Extinction Coefficient [280nm] NA

Activity

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct580 nM+/-277Brust A. et al. (2016)

Synthetic variants

References
Luo,S., Zhangsun,D., Zhang,B., Chen,X. and Feng,J. (2006) Direct cDNA cloning of novel conotoxins of the T-superfamily from Conus textile Peptides 27:2640-2646
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem.

Internal links
Protein Precursor Conorphin-T precursor (6097)
Conorphin-T precursor (646)
Conorphin-T precursor (1678)
Nucleic acids
Structure

External links
Ncbi Q3YEH2

Tools