Conorphin-T[I7(Nal),ribbon] (P06912) Protein Card

General Information
Name Conorphin-T[I7(Nal),ribbon] (named by ConoServer)
Alternative name(s) 16(1-2,3-4)
Organism synthetic construct
Protein Type Synthetic
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Cysteine framework V
Pharmacological family

Sequence
NCCRRQ(Nal)CC(nh2)
Modified residues
positionsymbolname
7Nal1-naphtyl-alanine
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1177.39
Monoisotopic Mass 1176.42
Isoelectric Point 12.50
Extinction Coefficient [280nm] 420.00

Activity

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct2.9 nM+/-0.8Brust A. et al. (2016)

References
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem.

Internal links
Nucleic acids
Structure

External links

Tools