GVIIJ[(Btr)2W,(Scc)24(Smc)] (P06953) Protein Card

General Information
Name GVIIJ[(Btr)2W,(Scc)24(Smc)] (named by ConoServer)
Alternative name(s) GVIIJ[SSMe]
Organism synthetic construct
Protein Type Synthetic
Parent GVIIJ

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
GWCGDOGATCGKLRLYCCSGFCD(Smc)YTKTCKDKSSA
Modified residues
positionsymbolname
6O4-Hydroxyproline
24SmcS-methylthio cysteine
Sequence evidence protein level
Average Mass 3785.30
Monoisotopic Mass 3782.49
Isoelectric Point 10.68
Extinction Coefficient [280nm] 8480.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus(Expressed in X. laevis oocytes. Kon & Koff rate constants recorded +/- SD in original article.)0.0026 μMZhang,M.M. et al. (2015)
Nav1.6M. musculus(Expressed in X. laevis oocytes. Kon & Koff rate constants recorded +/- SD in original article.)0.069 μMZhang,M.M. et al. (2015)

References
Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D. (2015) Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry 54:3911-3920

Internal links
Nucleic acids
Structure

External links

Tools