GVIIJ[BTr2W, SCC24MSC] (P06954) Protein Card

General Information
Name GVIIJ[BTr2W, SCC24MSC] (named by ConoServer)
Alternative name(s) GVIIJ[SSES]
Organism
Protein Type Synthetic
Parent GVIIJ

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
GWCGDOGATCGKLRLYCCSGFCD(MSC)YTKTCKDKSSA
Modified residues
positionsymbolname
6O4-Hydroxyproline
24MSC2-mercaptoethanesulfonate-cysteine
Sequence evidence protein level
Average Mass 3878.37
Monoisotopic Mass 3875.45
Isoelectric Point 10.68
Extinction Coefficient [280nm] 8480.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus(Expressed in X. laevis oocytes. Kon & Koff rate constants recorded +/- SD in original article.)0.0097 μMZhang,B. and Huang,F. and Du,W. (2012)
Nav1.6M. musculus(Expressed in X. laevis oocytes. Kon & Koff rate constants recorded +/- SD in original article.)0.253 μMZhang,B. and Huang,F. and Du,W. (2012)

References
Zhang,M.M., Gajewiak,J., Azam,L., Bulaj,G., Olivera,B.M. and Yoshikami,D. (2015) Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry 54:3911-3920

Internal links
Nucleic acids
Structure

External links

Tools