GVIIJ[BTr2W, SCC24S] (P06956) Protein Card

General Information
Name GVIIJ[BTr2W, SCC24S]
Alternative name(s) GVIIJ[C24S]
Organism
Protein Type Synthetic
Parent GVIIJ
Notes Block of rat Nav1.2 is rapidly reversible (Green et al., 2016).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
GWCGDOGATCGKLRLYCCSGFCDCYTKTCKDKSSA
Modified residues
positionsymbolname
6O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3739.22
Monoisotopic Mass 3736.50
Isoelectric Point 10.10
Extinction Coefficient [280nm] 8605.00

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav1.2R. norvegicus(Expressed in X. laevis oocytes.)4.8 μmGreen,B.R. et al. (2016)

References
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. (2016) Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. 291:7205-7220

Internal links
Nucleic acids
Structure

External links

Tools