BuIIIB[E3(Gla),C5U,C6A,C17U,C23A] (P07002) Protein Card

General Information
Name BuIIIB[E3(Gla),C5U,C6A,C17U,C23A]
Organism synthetic construct
Protein Type Synthetic
Parent BuIIIB

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family mu conotoxin

Sequence
VG(Gla)R(Sec)AKNGKRGCGRW(Sec)RDHSRAC(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
5SecSelenocysteine
17SecSelenocysteine
25nh2C-term amidation
Average Mass 2709.68
Monoisotopic Mass 2833.14
Isoelectric Point 12.36
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.3R. norvegicus0.33 μM+/-0.077Green,B.R. et al. (2014)

References
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2014) Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. 281:2885-2898

Internal links
Nucleic acids
Structure

External links

Tools