BuIIIB[E3(Dab),C5U,C6A,C17U,C23A] (P07003) Protein Card

General Information
Name BuIIIB[E3(Dab),C5U,C6A,C17U,C23A]
Organism synthetic construct
Protein Type Synthetic
Parent BuIIIB

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family mu conotoxin

Sequence
VG(Dab)R(Sec)AKNGKRGCGRW(Sec)RDHSRAC(nh2)
Modified residues
positionsymbolname
Average Mass 2636.67
Monoisotopic Mass 2760.17
Isoelectric Point 12.69
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.3R. norvegicus0.038 μM+/-0.003Green,B.R. et al. (2014)

References
Green,B.R., Zhang,M.M., Chhabra,S., Robinson,S.D., Wilson,M.J., Redding,A., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2014) Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. FEBS J. 281:2885-2898

Internal links
Nucleic acids
Structure

External links

Tools