Mo3964 (P07063) Protein Card

General Information
Name Mo3964
Organism Conus monile
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes This peptide defines a new Cys framework. Mo3964 reduced the outward currents that are due to the opening of voltage gated K+ channels in DRG neurons (Kancherla 2015). Leftward shift in the presence of Mo3964 was observed in averaged normalized conductance-voltage plot of outward Na+ currents (Kancherla 2015).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework XXVII
Pharmacological family delta conotoxin
kappa conotoxin

Sequence
DGECGDKDEPCCGRPDGAKVCNDPWVCILTSSRCENP
Sequence evidence nucleic acid level
Average Mass 3964.32
Monoisotopic Mass 3961.59
Isoelectric Point 4.50
Extinction Coefficient [280nm] 5500.00

References
Kancherla,A.K., Meesala,S., Jorwal,P., Palanisamy,R., Sikdar,S.K. and Sarma,S.P. (2015) A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin. ACS Chem. Biol. 10:1847-1860

Internal links
Nucleic acids
Structure Solution NMR structure of a novel cysteine framework containing Conus peptide Mo3964

External links
UniProtKB/Swiss-Prot A0A0R4I952

Tools