Conantokin-SuE (P07407) Protein Card

General Information
Name Conantokin-SuE (named by ConoServer)
Alternative name(s) Con-BkE
Organism Conus sulcatus
Organism region Indo-Pacific
Protein Type Wild type
Protein precursor Conantokin-SuE precursor incomplete (7408)
Notes Conus bocki is renamed as Conus Sulcatus

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)CS(Gla)AI(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1097.02
Monoisotopic Mass 1096.35
Isoelectric Point 0.85
Extinction Coefficient [280nm] 125.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50Ref
GluN2AR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)>10 uMPlatt,R.J. et al. (2014)
GluN2BR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)>10 uMPlatt,R.J. et al. (2014)
GluN2CR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)>10 uMPlatt,R.J. et al. (2014)
GluN2DR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)>10 uMPlatt,R.J. et al. (2014)

References
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., GruszczyƄski,P., Bulaj,G., Horvath,M.P. and Olivera,B.M. (2014) From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon 81:67-79

Internal links
Protein Precursor Conantokin-SuE precursor incomplete (7408)
Nucleic acids Conantokin-SuE precursor incomplete
Structure

External links

Tools