AuIB[Y5A] (P07417) Protein Card

General Information
Name AuIB[Y5A]
Organism synthetic construct
Protein Type Synthetic
Parent AuIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSAPPCFATNPDC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1480.66
Monoisotopic Mass 1479.50
Isoelectric Point 2.19
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β4R. norvegicus(Adapted from reported "relative current amplitude")67+/-23 uM50 uM AChGrishin,A.A. et al. (2013)

References
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J. (2013) Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. 288:34428-34442

Internal links
Nucleic acids
Structure

External links

Tools