AuIB[F9(Nal)] (P07421) Protein Card

General Information
Name AuIB[F9(Nal)] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSYPPC(Nal)ATNPDC(nh2)
Modified residues
positionsymbolname
9NalNapthylalanine
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1622.81
Monoisotopic Mass 1621.54
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β4R. norvegicus(Adapted from reported "relative current amplitude")18+/-710 uM50 uM AChGrishin,A.A. et al. (2013)

References
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J. (2013) Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. 288:34428-34442

Internal links
Nucleic acids
Structure

External links

Tools