KIIIB (P07434) Protein Card

General Information
Name KIIIB
Alternative name(s) KIIIB-P2
Organism Conus kinoshitai
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Predominant disulfide isomer: [1-5/2-4/3-6]

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NGCCNCSSKWCRDHSRCC(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2055.29
Monoisotopic Mass 2053.70
Isoelectric Point 11.62
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus0.026 uM+/-0.014Khoo,K.K. et al. (2012)

Synthetic variants
KIIIB-P1NGCCNCSSKWCRDHSRCC(nh2)

References
Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S. (2012) Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry 51:9826-9835

Internal links
Nucleic acids
Structure

External links

Tools