TIA[del1-3] (P07442) Protein Card

General Information
Name TIA[del1-3] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent TIA
Notes ~89% inhibition of the noradrenergic component of rat vas deferens contraction at 10 uM. (Sharpe et al. 2003)

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family rho conotoxin

Sequence
RCCLIPACRRNHKKFC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1943.40
Monoisotopic Mass 1941.95
Isoelectric Point 12.82
Extinction Coefficient [280nm] NA

References
Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2003) Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. 278:34451-34457

Internal links
Nucleic acids
Structure

External links

Tools