TIA[N2A] (P07445) Protein Card

General Information
Name TIA[N2A] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent TIA
Notes Reduced inhibition of prazosin binding to a1-adrenoreceptors - pIC50 ~7.2 compared to native TIA (pIC50 ~7.5). (Sharpe et al., 2003)

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family rho conotoxin

Sequence
FAWRCCLIPACRRNHKKFC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Sequence evidence protein level
Average Mass 2347.87
Monoisotopic Mass 2346.14
Isoelectric Point 12.82
Extinction Coefficient [280nm] 5500.00

References
Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2003) Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. 278:34451-34457

Internal links
Nucleic acids
Structure

External links

Tools