SIIIA[del1,W12A] (P07453) Protein Card

General Information
Name SIIIA[del1,W12A] (named by ConoServer)
Alternative name(s) [W12A]SIIIA-(2–20)
Organism synthetic construct
Protein Type Synthetic
Parent SIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NCCNGGCSSKACRDHARCC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Sequence evidence protein level
Average Mass 1981.21
Monoisotopic Mass 1979.68
Isoelectric Point 11.62
Extinction Coefficient [280nm] NA

Activity

Ki: Voltage-Gated Sodium Channels

TargetOrganismKiCompetitorAgonistRef
Nav1.2R. norvegicus(Measured in rat brain preparation.)116.7 nM125I-TIIIASchroeder,C.I. et al. (2008)
Nav1.4R. norvegicus(Measured in rat muscle preparation.)3518.8 nM125I-TIIIASchroeder,C.I. et al. (2008)

References
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2008) Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. 283:21621-21628

Internal links
Nucleic acids
Structure

External links

Tools