SIIIA[del1,R14A] (P07454) Protein Card

General Information
Name SIIIA[del1,R14A] (named by ConoServer)
Alternative name(s) [R14A]SIIIA-(2–20)
Organism synthetic construct
Protein Type Synthetic
Parent SIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NCCNGGCSSKWCADHARCC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Sequence evidence protein level
Average Mass 2011.23
Monoisotopic Mass 2009.66
Isoelectric Point 9.95
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Voltage-Gated Sodium Channels

TargetOrganismKiCompetitorAgonistRef
Nav1.2R. norvegicus(Measured in rat brain preparation.)33.56 nM125I-TIIIASchroeder,C.I. et al. (2008)
Nav1.4R. norvegicus(Measured in rat muscle preparation.)2523 nM125I-TIIIASchroeder,C.I. et al. (2008)

References
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2008) Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. 283:21621-21628

Internal links
Nucleic acids
Structure

External links

Tools