SIIIA[del1,K11R,W12A] (P07458) Protein Card

General Information
Name SIIIA[del1,K11R,W12A] (named by ConoServer)
Alternative name(s) [R11,A12]SIIIA-(2–20)
Organism synthetic construct
Protein Type Synthetic
Parent SIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NCCNGGCSSRACRDHARCC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Sequence evidence protein level
Average Mass 2009.22
Monoisotopic Mass 2007.69
Isoelectric Point 12.20
Extinction Coefficient [280nm] NA

Activity

Ki: Voltage-Gated Sodium Channels

TargetOrganismKiCompetitorAgonistRef
Nav1.2R. norvegicus(Measured in rat brain preparation.)0.62 nM125I-TIIIASchroeder,C.I. et al. (2008)
Nav1.4R. norvegicus(Measured in rat muscle preparation.)17.26 nM125I-TIIIASchroeder,C.I. et al. (2008)

References
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2008) Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. 283:21621-21628

Internal links
Nucleic acids
Structure

External links

Tools