cRgIA-6 (P07470) Protein Card

General Information
Name cRgIA-6
Organism synthetic construct
Protein Type Synthetic
Parent RgIA
Notes Inhibited HVA Ca2+ channel current via GABAB receptors in rat DRG neurons with an IC50 of 4.3 nM. (Halai 2011)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCRYRCGGAAGG
Sequence evidence protein level
Average Mass 1766.96
Monoisotopic Mass 1765.66
Isoelectric Point 12.80
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α9α10unidentified(nAChR was hybrid human α9/rat α10. )>50 nMHalai,R. et al. (2011)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α9α10unidentified(nAChR was hybrid human α9/rat α10. )39+/-450 nMHalai,R. et al. (2011)

References
Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J. (2011) Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. 54:6984-6992

Internal links
Nucleic acids
Structure

External links

Tools