GID [(Gla)4E, A10V] (P07502) Protein Card

General Information
Name GID [(Gla)4E, A10V] (named by ConoServer)
Alternative name(s) α-GID[A10V]
Organism synthetic construct
Protein Type Synthetic
Parent GID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
IRDECCSNPVCRVNNOHVC
Modified residues
positionsymbolname
16O4-Hydroxyproline
Average Mass 2170.43
Monoisotopic Mass 2168.90
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2H. sapiens0.01 uMAch (1 uM)Leffler,A.E. et al. (2017)
α3β4H. sapiens>10 uMAch (5 uM)Leffler,A.E. et al. (2017)
α4β2H. sapiens3 uMAch (0.5 uM)Leffler,A.E. et al. (2017)
α7H. sapiens0.1 uMAch (30 uM)Leffler,A.E. et al. (2017)

References
Leffler,A.E., Kuryatov,A., Zebroski,H.A., Powell,S.R., Filipenko,P., Hussein,A.K., Gorson,J., Heizmann,A., Lyskov,S., Tsien,R.W., Poget,S.F., Nicke,A., Lindstrom,J., Rudy,B., Bonneau,R. and Holford,M. (2017) Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc. Natl. Acad. Sci. U.S.A. 114

Internal links
Nucleic acids
Structure NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID MUTANT A10V

External links

Tools