TsIIIA (P07525) Protein Card

General Information
Name TsIIIA
Organism Conus tessulatus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor TsIIIA precursor (7526)
Notes Yang et al.,2017 reported that TsIIIA increased the pain threshold in a mice hotplate analgesic assay at 0.5-4 h. Yang and Zhou (2020) reported that TsIIIA provides a pharmacological probe for sodium channels and a potential therapeutic agent for pain.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
GCCRWPCPSRCGMARCCSS
Sequence evidence nucleic acid level
Average Mass 2057.41
Monoisotopic Mass 2055.72
Isoelectric Point 12.80
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50nhillRef
Nav1.1H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.2H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.3H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.4H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.5H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.6H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.7H. sapiens>10 μMYang,M. and Zhou,M. (2020)
Nav1.8H. sapiens(2 μM TsIIIA did not induce a shift in the current voltage relationship of hNav1.8)2.11 μMYang,M. and Zhou,M. (2020)
Nav TTX-RR. norvegicus2.61uM5Yang,M. et al. (2017)

References
Yang,M., Zhao,S., Min,X., Shao,M., Chen,Y., Chen,Z. and Zhou,M. (2017) A novel μ-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon 130:11-18
Yang,M. and Zhou,M. (2020) μ-conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNav1.8. Toxicon 186:29-34

Internal links
Protein Precursor TsIIIA precursor (7526)
Nucleic acids
Structure

External links

Tools