ConoGAY-AusB (P07535) Protein Card

General Information
Name ConoGAY-AusB (named by ConoServer)
Alternative name(s) AusB
Organism Conus australis
Protein Type Wild type
Notes Lebbe et al., 2016 reported that ConoGAY-AusB has no activity against 29 Gram-negative and 10 Gram-positive bacterial strains and two yeast strains.

Classification
Conopeptide class conoGAY
Gene superfamily
Pharmacological family

Sequence
GAYFDGFDVPCVPRRDDC
Sequence evidence protein level
Average Mass 2030.21
Monoisotopic Mass 2028.84
Isoelectric Point 4.96
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.1R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.2R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.3H. sapiens010 uMLebbe,E.K. et al. (2016)
Kv1.4R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.5R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.6R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv10.1H. sapiens010 uMLebbe,E.K. et al. (2016)
Kv11.1H. sapiens(ERG)010 uMLebbe,E.K. et al. (2016)

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.1R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.2R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.3R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.4R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.5H. sapiens010 uMLebbe,E.K. et al. (2016)
Nav1.6M. musculus010 uMLebbe,E.K. et al. (2016)
Nav1.8H. sapiens010 uMLebbe,E.K. et al. (2016)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α1β1δεR. norvegicus010 uM Lebbe,E.K. et al. (2016)
α3β4H. sapiens010 uM Lebbe,E.K. et al. (2016)
α4β2H. sapiens010 uM Lebbe,E.K. et al. (2016)
α4β4H. sapiens010 uM Lebbe,E.K. et al. (2016)
α7G. gallus010 uM Lebbe,E.K. et al. (2016)

References
Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. (2016) Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs 14

Internal links
Nucleic acids
Structure

External links

Tools