MrIA [N1Z, C4[HCY], C5[HCY], C10[HCY], C13[HCY]] (P07639) Protein Card

General Information
Name MrIA [N1Z, C4[HCY], C5[HCY], C10[HCY], C13[HCY]] (named by ConoServer)
Organism synthetic construct
Protein Type Patent
Parent MrIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework X
Pharmacological family chi conotoxin

Sequence
ZGVXXGYKLXHOX(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
4XHomocysteine
5XHomocysteine
10XHomocysteine
12O4-Hydroxyproline
13XHomocysteine
14nh2C-term amidation
Sequence evidence protein level
Average Mass 1464.79
Monoisotopic Mass 1463.62
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Monoamine transporter

TargetOrganismIC50CompetitorRef
NETH. sapiens>100uM[3H]nisoxetine 4.3 nMBrust,A. et al. (2009)

References
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. (2009) chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 52:6991-7002

Internal links
Nucleic acids
Structure

External links

Tools