MoVIB (P07646) Protein Card

General Information
Name MoVIB
Organism Conus moncuri
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor MoVIA/B precursor (7648)
Notes MoVIB was anaglesic in a Rat Model of Neuropathic Pain when injected intrathecally (Sousa 2018).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKPOGSKCSOSMRDCCTTCISYTKRCRKYY
Modified residues
positionsymbolname
4O4-Hydroxyproline
10O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3493.05
Monoisotopic Mass 3490.48
Isoelectric Point 12.35
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50Ref
Cav2.2H. sapiens600+/-12Sousa,S.R. et al. (2018)

Synthetic variants
MoVIB[R13Y]CKPOGSKCSOSMYDCCTTCISYTKRCRKYY

References
Sousa,S.R., McArthur,J.R., Brust,A., Bhola,R.F., Rosengren,K.J., Ragnarsson,L., Dutertre,S., Alewood,P.F., Christie,M.J., Adams,D.J., Vetter,I. and Lewis,R.J. (2018) Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep 8:13397

Internal links
Protein Precursor MoVIA/B precursor (7648)
Nucleic acids
Structure Solution NMR structure of the omega conotoxin MoVIB from Conus moncuri

External links

Tools