MoVIB[R13Y] (P07649) Protein Card

General Information
Name MoVIB[R13Y]
Organism synthetic construct
Protein Type Synthetic
Parent MoVIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKPOGSKCSOSMYDCCTTCISYTKRCRKYY
Modified residues
positionsymbolname
4O4-Hydroxyproline
10O4-Hydroxyproline
Average Mass 3500.03
Monoisotopic Mass 3497.45
Isoelectric Point 12.02
Extinction Coefficient [280nm] 5960.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50Ref
Cav2.2H. sapiens3.47uM+/-0.55Sousa,S.R. et al. (2018)

References
Sousa,S.R., McArthur,J.R., Brust,A., Bhola,R.F., Rosengren,K.J., Ragnarsson,L., Dutertre,S., Alewood,P.F., Christie,M.J., Adams,D.J., Vetter,I. and Lewis,R.J. (2018) Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep 8:13397

Internal links
Nucleic acids
Structure

External links

Tools