VnIB (P07652) Protein Card

General Information
Name VnIB
Organism Conus ventricosus
Organism region Eastern Atlantic and Mediterranean
Organism diet molluscivorous
Protein Type Wild type
Protein precursor VnIB precursor (7653)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSHPVCYTKNPNCG
Sequence evidence nucleic acid level
Average Mass 1735.93
Monoisotopic Mass 1734.64
Isoelectric Point 10.45
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α1β1δεH. sapiens>10 uMVan Hout et al. (2019)
α2β2R. norvegicus>10 uMVan Hout et al. (2019)
α2β4R. norvegicus>10 uMVan Hout et al. (2019)
α3β2R. norvegicus>10 uMVan Hout et al. (2019)
α3β4H. sapiens>10 uMVan Hout et al. (2019)
R. norvegicus320nM[250-390]1.2Van Hout et al. (2019)
α4β2H. sapiens>10 uMVan Hout et al. (2019)
R. norvegicus>10 uMVan Hout et al. (2019)
α4β4R. norvegicus>10 uMVan Hout et al. (2019)
α6β4R. norvegicus12nM[9.9-15]1.2Van Hout et al. (2019)
α6/α3β2β3H. sapiens>10 uMVan Hout et al. (2019)
R. norvegicus4000nM[2500-6900]0.53Van Hout et al. (2019)
α6/α3β4H. sapiens5.3nM [4.1-6.9]1.1Van Hout et al. (2019)
R. norvegicus18nM[16-20]1.1Van Hout et al. (2019)
α7R. norvegicus>10 uMVan Hout et al. (2019)
α9α10R. norvegicus>10 uMVan Hout et al. (2019)

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α6β4R. norvegicus11.7nM+/-5.01Van Hout et al. (2019)

References
Van Hout, M., Valdes, A., Christensen, S.B., Tran, P.T., Watkins, M., Gajewiak, J., Jensen, A.A., Olivera, B.M. and McIntosh, J.M. (2019) α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors Neuropharmacology 157:107691

Internal links
Protein Precursor VnIB precursor (7653)
Nucleic acids
Structure

External links
Ncbi MK120500

Tools