RgIA [R13r] (P07654) Protein Card

General Information
Name RgIA [R13r] (named by ConoServer)
Alternative name(s) RgIA-13
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCRYRCr
Modified residues
positionsymbolname
13rD-arginine
Sequence evidence protein level
Average Mass 1570.79
Monoisotopic Mass 1569.62
Isoelectric Point 12.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens1050 nM[700-1590]0.46Ren et al. (2019)
R. norvegicus1.33 nM[1.086-1.638]0.99Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools