RgIA [R13r] (P07654) Protein Card

General Information
Name RgIA [R13r] (named by ConoServer)
Alternative name(s) RgIA-13
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCRYRCr
Modified residues
positionsymbolname
13rD-arginine
Sequence evidence protein level
Average Mass 1570.79
Monoisotopic Mass 1569.62
Isoelectric Point 12.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens1050 nM0.46Ren et al. (2019)
R. norvegicus1.33 nM0.99Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools