RgIA [R7r,R9r,R11r,del13] amidated (P07656) Protein Card

General Information
Name RgIA [R7r,R9r,R11r,del13] amidated (named by ConoServer)
Alternative name(s) RgIA-15
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPrCrYrC(nh2)
Modified residues
positionsymbolname
7rD-arginine
9rD-arginine
11rD-arginine
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1413.62
Monoisotopic Mass 1412.53
Isoelectric Point 12.20
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens680 nM1.47Ren et al. (2019)
R. norvegicus288.5 nM0.72Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools