RgIA [R7r,R9r,R11r,del13] amidated (P07656) Protein Card

General Information
Name RgIA [R7r,R9r,R11r,del13] amidated (named by ConoServer)
Alternative name(s) RgIA-15
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPrCrYrC(nh2)
Modified residues
positionsymbolname
7rD-arginine
9rD-arginine
11rD-arginine
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1413.62
Monoisotopic Mass 1412.53
Isoelectric Point 12.20
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens680 nM[650-720]1.47Ren et al. (2019)
R. norvegicus288.5 nM[224.9-398.9]0.72Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools