RgIA [C3c] (P07659) Protein Card

General Information
Name RgIA [C3c] (named by ConoServer)
Alternative name(s) RgIA-3
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCcSDPRCRYRCR
Modified residues
positionsymbolname
3cD-cysteine
Sequence evidence protein level
Average Mass 1571.80
Monoisotopic Mass 1570.62
Isoelectric Point 12.03
Extinction Coefficient [280nm] 1615.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens6440 nM[1490-2790]0.51Ren et al. (2019)
R. norvegicus31.77 nM[26.66-37.87]0.84Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools