RgIA [S4s] (P07660) Protein Card

General Information
Name RgIA [S4s] (named by ConoServer)
Alternative name(s) RgIA-4
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCsDPRCRYRCR
Modified residues
positionsymbolname
4sD-serine
Sequence evidence protein level
Average Mass 1570.79
Monoisotopic Mass 1569.62
Isoelectric Point 12.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α9α10H. sapiens>10uMRen et al. (2019)
R. norvegicus>10uMRen et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142
Grau, V., Richter, K., Hone, A.J. and McIntosh, J.M. (2018) Conopeptides [V11L; V16D] ArIB and RgIA4: powerful tools for the identification of novel nicotinic acetylcholine receptors in monocytes Frontiers in pharmacology 9

Internal links
Nucleic acids
Structure

External links

Tools