RgIA [R9r] (P07665) Protein Card

General Information
Name RgIA [R9r] (named by ConoServer)
Alternative name(s) RgIA-9
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCrYRCR
Modified residues
positionsymbolname
9rD-arginine
Sequence evidence protein level
Average Mass 1570.79
Monoisotopic Mass 1569.62
Isoelectric Point 12.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens>10uMRen et al. (2019)
R. norvegicus1752nM[1351-2272]1.02Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools