RgIA [C12c] (P07668) Protein Card

General Information
Name RgIA [C12c] (named by ConoServer)
Alternative name(s) RgIA-12
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCRYRcR
Modified residues
positionsymbolname
12cD-cysteine
Sequence evidence protein level
Average Mass 1571.80
Monoisotopic Mass 1570.62
Isoelectric Point 12.03
Extinction Coefficient [280nm] 1615.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillRef
α9α10H. sapiens>10uMRen et al. (2019)
R. norvegicus533.4nM[389.9-729.6]0.71Ren et al. (2019)

References
Ren, J., Zhu, X., Xu, P., Li, R., Fu, Y., Dong, S., Zhangsun, D., Wu, Y. and Luo, S. (2019) d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability Marine drugs 17:142

Internal links
Nucleic acids
Structure

External links

Tools