CIB (P08017) Protein Card

General Information
Name CIB
Alternative name(s) Ca003
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Giribaldi J., et al reported that CIB is inactivity on the muscle and α4β2 subtypes at concentrations up to 10 μM.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPVCHLEHPNAC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1678.89
Monoisotopic Mass 1677.63
Isoelectric Point 6.81
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus128.9 uM100 uMGiribaldi et al. (2018)
α7R. norvegicus 1.51 uM100 uMGiribaldi et al. (2018)

References
Giribaldi, J., Wilson, D., Nicke, A., El Hamdaoui, Y., Laconde, G., Faucherre, A., Moha Ou Maati, H., Daly, N., Enjalbal, C. and Dutertre, S. (2018) Synthesis, structure and biological activity of CIA and CIB, two α-conotoxins from the predation-evoked venom of Conus catus Toxins 10:222
Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research 14:4372-4381

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0DPT2

Tools