SIIIA precursor (P00825) Protein Card

General Information
Name SIIIA precursor
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Pharmacological family

Sequence
MMSKLGVLLTVCPLLFPLTA
LPPDGDQPADRPAERMQDDIS
SDEHPLFDKR
QNCCNGGCSSKWCRDHARCC
GR
Sequence region
[1-20]signal sequence
[52-71]mature peptideSIIIA

References
Wang,C.Z., Zhang,H., Jiang,H., Lu,W., Zhao,Z.Q. and Chi,C.W. (2006) A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels Toxicon 47:122-132
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M. (2005) Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels Biochemistry 44:7259-7265
Bulaj,G., West,P.J., Garrett,J.E., Watkins,M., Zhang,M.-M., Norton,R.S., Smith,B.J., Yoshikami,D. and Olivera,B.M. (2006) Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry 45:3116

Internal links
Nucleic acids Conus striatus mu conotoxin SIIIA precursor, mRNA, complete cds
Structure

External links
UniProtKB/Swiss-Prot Q86DU6
Ncbi Q86DU6, AAO48588

Tools