Conorfamide-Tx1 (P08367) Protein Card

General Information
Name Conorfamide-Tx1 (named by ConoServer)
Alternative name(s) CNF-Tx1
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Conorfamide-Tx1 precursor (8366)
Notes Espino et al.2018 reported that Conorfamide-Tx1 against human MRGPRX1 and mouse MRGPRC11 at 10 ┬ÁM are inactive.

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Sequence
PGVLDIPVKSNSDDDSIFRY(nh2)
Modified residues
positionsymbolname
21nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2236.47
Monoisotopic Mass 2235.12
Isoelectric Point 4.96
Extinction Coefficient [280nm] 1490.00

References
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Protein Precursor Conorfamide-Tx1 precursor (8366)
Nucleic acids
Structure

External links

Tools