Conorfamide-Tx2 (P08369) Protein Card

General Information
Name Conorfamide-Tx2 (named by ConoServer)
Alternative name(s) CNF-Tx2
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Conorfamide-Tx2 precursor (8368)
Notes Espino et al.2018 reported that Conorfamide-Tx2 against mouse MRGPRC11 at 10 µM is inactive.

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Sequence
HSGILLAWSGPRNRFVRI(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2078.46
Monoisotopic Mass 2077.18
Isoelectric Point 12.80
Extinction Coefficient [280nm] 5500.00

Activity

EC50: Class A Orphans

TargetOrganismEC50Ref
MRGPRX1H. sapiens0.54 µMEspino et al. (2018)

References
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Protein Precursor Conorfamide-Tx2 precursor (8368)
Nucleic acids
Structure

External links

Tools