RXIA (P00840) Protein Card

General Information
Name RXIA
Alternative name(s) R11.6,r11a
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor RXIA precursor (4225)
Notes The mutation f44>F leads to a loss of activity in amphibian axons (Buczek et al 2005).

Classification
Conopeptide class conotoxin
Gene superfamily I1 superfamily
Cysteine framework XI
Pharmacological family iota conotoxin

Sequence
GOSFCKADEKOCEYHADCCNCCLSGICAOSTNWILPGCSTS
SFfKI
Modified residues
positionsymbolname
2O4-Hydroxyproline
11O4-Hydroxyproline
29O4-Hydroxyproline
44fD-phenylalanine
Sequence evidence protein level
Average Mass 4975.58
Monoisotopic Mass 4972.02
Isoelectric Point 5.96
Extinction Coefficient [280nm] 6990.00

Synthetic variants
RXIA [BTr33>W]IKfFSSTSCGPLIWNTSOACIGSLCCNCCDAHYECOKEDAKCFSOG

References
Jimenez,E.C., Shetty,R.P., Lirazan,M., Rivier,J., Walker,C., Abogadie,F.C., Yoshikami,D., Cruz,L.J. and Olivera,B.M. (2003) Novel excitatory Conus peptides define a new conotoxin superfamily J. Neurochem. 85:610-621
Buczek,O., Yoshikami,D., Bulaj,G., Jimenez,E.C. and Olivera,B.M. (2005) Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide J. Biol. Chem. 280:4247-4253
Buczek,O., Jimenez,E.C., Yoshikami,D., Imperial,J.S., Watkins,M., Morrison,A. and Olivera,B.M. (2008) I(1)-superfamily conotoxins and prediction of single D-amino acid occurrence. Toxicon 51:218-229
Buczek,O., Wei,D., Babon,J.J., Yang,X., Fiedler,B., Chen,P., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S. (2007) Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry 46:9929-9940

Internal links
Protein Precursor RXIA precursor (4225)
Nucleic acids
Structure STRUCTURE AND SODIUM CHANNEL ACTIVITY OF AN EXCITATORY I1- SUPERFAMILY CONOTOXIN
NMR structure of iota-RXIA

External links
UniProtKB/Swiss-Prot Q7Z094
Ncbi 2JRY_A, 2P4L_A, Q7Z094, AAP41541

Tools