TxID[S9E] (P08426) Protein Card

General Information
Name TxID[S9E]
Organism synthetic construct
Protein Type Synthetic
Parent TxID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPVCEAMSPIC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Average Mass 1531.81
Monoisotopic Mass 1530.55
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β4R. norvegicus320 nM[240-420]0.9Ach (100 uM)Yu et al. (2018)
α6/α3β4R. norvegicus >10 μMAch (100 uM)Yu et al. (2018)

References
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Nucleic acids
Structure

External links

Tools