TxID[S9s] (P08427) Protein Card

General Information
Name TxID[S9s]
Organism synthetic construct
Protein Type Synthetic
Parent TxID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPVCsAMSPIC(nh2)
Modified residues
positionsymbolname
9sD-serine
16nh2C-term amidation
Average Mass 1489.77
Monoisotopic Mass 1488.54
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β4R. norvegicus120 nM[90-170]0.9Ach (100 uM)Yu et al. (2018)
α6/α3β4R. norvegicus500 nM[360-700]0.7Ach (100 uM)Yu et al. (2018)

References
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Nucleic acids
Structure

External links

Tools