TxIB[K11A] (P08486) Protein Card

General Information
Name TxIB[K11A]
Organism synthetic construct
Protein Type Synthetic
Parent TxIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSDPPCRNAHPDLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1682.87
Monoisotopic Mass 1681.62
Isoelectric Point 5.80
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7H. sapiens>10000 nM200 uM AchYu et al. (2018)
R. norvegicus200 nM[160-250]1200 uM Ach Yu et al. (2018)

References
Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D., Kasheverov, I., Lei, Y., Zhangsun, D., Tsetlin, V. and Luo, S. (2018) Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Neuropharmacology 139:226-237

Internal links
Nucleic acids
Structure

External links

Tools