Conantokin-G[E3D,E4D,L5Y,E7D,N8A,E10D,E14D] (P08500) Protein Card

General Information
Name Conantokin-G[E3D,E4D,L5Y,E7D,N8A,E10D,E14D] (named by ConoServer)
Alternative name(s) EAR 18
Organism synthetic construct
Protein Type Synthetic

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GEDDYQDAQDLIRDKSN
Average Mass 1982.01
Monoisotopic Mass 1980.87
Isoelectric Point 4.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2BR. norvegicus30.2 μMAch (500 uM)Reyes-Guzman et al. (2017)
GluN3AR. norvegicus18.4 μMAch (500 uM)Reyes-Guzman et al. (2017)

References
Reyes-Guzman, E.A., Vega-Castro, N., Reyes-Montaño, E.A. and Recio-Pinto, E. (2017) Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed BMC neuroscience 18:44

Internal links
Nucleic acids
Structure

External links

Tools