GeXIVA[C2S,C9S] (P08688) Protein Card

General Information
Name GeXIVA[C2S,C9S]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[bead]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TSRSSGRYSRSPYDRRRRYCRRITDACV
Average Mass 3422.82
Monoisotopic Mass 3420.68
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus1960 nM[1326-2893]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus9060 nM[1800-45600]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus3800 nM[2289-6296]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus8410 nM[4164-17000]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus>10000Ach (100 uM)Xu et al. (2020)
α7R. norvegicus1520 nM[638-3604]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus12 nM[9-15]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools