GeXIVA[C20A,C27A] (P08689) Protein Card

General Information
Name GeXIVA[C20A,C27A]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[bead]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TCRSSGRYCRSPYDRRRRYARRITDAAV
Average Mass 3390.82
Monoisotopic Mass 3388.69
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus2490 nM[1907-3242]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus3120 nM[1593-6127]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus3250 nM[1887-5604]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus6130 nM[3615-10410]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus8680 nM[6636-11360]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus1400 nM[826-2361]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus14 nM[11-18]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools