GeXIVA[C2A,C9A,C20A,C27A] (P08695) Protein Card

General Information
Name GeXIVA[C2A,C9A,C20A,C27A]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[bead]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TARSSGRYARSPYDRRRRYARRITDAAV
Average Mass 3328.72
Monoisotopic Mass 3326.77
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus2030 nM[1511-2725]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus7510 nM[3773-14950]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus3570 nM[1871-6804]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus8990 nM[3214-25160]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus>10000Ach (100 uM)Xu et al. (2020)
α7R. norvegicus3560 nM[2160-5870]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus14 nM[12-17]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools