GeXIVA[C2S,C9S,C20S,C27S] (P08696) Protein Card

General Information
Name GeXIVA[C2S,C9S,C20S,C27S]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[bead]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TSRSSGRYSRSPYDRRRRYSRRITDASV
Average Mass 3392.72
Monoisotopic Mass 3390.75
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus2730 nM[2083-3572]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus7520 nM[2844-19880]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus2090 nM[1400-2129]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus6630 nM[4045-10880]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus7340 nM[5234-10290]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus1690 nM[1092-2610]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus16 nM[11-22]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools