GeXIVA[C2A,C9A,C20S,C27S] (P08697) Protein Card

General Information
Name GeXIVA[C2A,C9A,C20S,C27S]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[bead]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TARSSGRYARSPYDRRRRYSRRITDASV
Average Mass 3360.72
Monoisotopic Mass 3358.76
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus2690 nM[2029-3562]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus4360 nM[2811-6764]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus2830 nM[1880-4269]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus8350 nM[5382-12940]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus>10000Ach (100 uM)Xu et al. (2020)
α7R. norvegicus1270 nM[769-2083]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus6.1 nM[4.8-7.6]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools