Conorfamide-As2a (P08701) Protein Card

General Information
Name Conorfamide-As2a
Organism Conus austini
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
RIRKPIFAFPRF(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1546.94
Monoisotopic Mass 1545.94
Isoelectric Point 12.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεH. sapiens208.4 nM[141.3-275.4]Ach (3 uM)Jin et al. (2019)
α7H. sapiens2029.2 nM[1659.6-2398.8]Ach (100 uM)Jin et al. (2019)

References
Jin, A.H., Cristofori-Armstrong, B., Rash, L.D., Román-González, S.A., Espinosa, R.A., Lewis, R.J., Alewood, P.F. and Vetter, I (2019) Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels Biochemical pharmacology 164:342-348

Internal links
Nucleic acids
Structure

External links

Tools