Lo6.1 (P08784) Protein Card

General Information
Name Lo6.1 (named by ConoServer)
Alternative name(s) Lo6/7a
Organism Conus longurionis
Protein Type Wild type
Notes Lebbe et al., 2016 reported that no activity of Lo6.1 against 29 Gram-negative and 10 Gram-positive bacterial strains and two yeast strains.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family

Sequence
DQCSYCGIYCCPPKFCTSAGCRSP(nh2)
Modified residues
positionsymbolname
25nh2C-term amidation
Sequence evidence protein level
Average Mass 2582.94
Monoisotopic Mass 2580.98
Isoelectric Point 10.53
Extinction Coefficient [280nm] 2980.00

Activity

Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.1R. norvegicus01 uMLebbe,E.K. et al. (2016)
Kv1.3H. sapiens01 uMLebbe,E.K. et al. (2016)
Kv1.4R. norvegicus01 uMLebbe,E.K. et al. (2016)
Kv1.5R. norvegicus01 uMLebbe,E.K. et al. (2016)
Kv1.6R. norvegicus01 uMLebbe,E.K. et al. (2016)
Kv3.1H. sapiens01 uMLebbe,E.K. et al. (2016)

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.1R. norvegicus01 uMLebbe,E.K. et al. (2016)
Nav1.2R. norvegicus01 uMLebbe,E.K. et al. (2016)
Nav1.3R. norvegicus01 uMLebbe,E.K. et al. (2016)
Nav1.4R. norvegicus01 uMLebbe,E.K. et al. (2016)
Nav1.5H. sapiens01 uMLebbe,E.K. et al. (2016)
Nav1.6M. musculus01 uMLebbe,E.K. et al. (2016)
Nav1.7R. norvegicus01 uMLebbe,E.K. et al. (2016)

References
Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. (2016) Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs 14

Internal links
Nucleic acids
Structure

External links

Tools